Adrenal Insufficiency

 

💡 Did you know some people live without adrenal glands at all?
This can happen due to:
🔹 Surgery – for tumors like pheochromocytoma or Cushing’s
🔹 Metastatic cancer – when cancer spreads to both adrenal glands
🔹 Bleeding into the glands, infections like TB
🔹 Or genetic conditions (like CAH) where glands are non-functional
🧬 In all these cases, the result is the same:
➡️ No cortisol. No aldosterone. No hormone backup.
This is called absolute adrenal insufficiency.
📌 When you have no adrenal glands, your body relies 100% on replacement therapy. There’s zero margin for error – even a delayed dose or skipped salt can lead to crisis.
👉 That’s why we made today’s image – with everything you NEED to know if you (or someone you love) is living without adrenal glands.
💙 Save it. Share it. Advocate.

❓Clinical Trial: Congenital Adrenal Hyperplasia (CAH)


The CAHmelia clinical trials are exploring a new investigational treatment for classic CAH.

CAHmelia 203 and CAHmelia 204 are clinical trials to test tildacerfont in adults with classic CAH, which may offer you and your loved ones hope of a brighter future – one where you may not have to choose between symptom management and long-term health.
Tildacerfont is a new type of oral, once-daily investigational treatment – one that is not a steroid – that is currently being tested in adults with classic CAH. By reducing the amount of androgens your body makes, tildacerfont may improve your classic CAH symptoms.
This investigational treatment will not replace your steroid treatment but may allow you to manage your disease with lower amounts of steroids at normal or near-normal doses.

Who can take part in this trial? You may be able to take part if you:Are at least 18 years of ageHave a confirmed diagnosis of classic CAH due to 21-OH deficiencyHave been on the same daily dose of steroids (GCs and/or mineralocorticoids) for at least 1 month before starting the trialBoth trials are now open for enrollment.
Tildacerfont is an investigational treatment not authorized for use in people outside the clinical trial.
For more information, go to: clarahealth.com/studies/cahmelia

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